pentobarbital will decrease the level or outcome of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or effect of repaglinide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Reserve concomitant prescribing of those drugs in individuals for whom other remedy alternatives are inadequate. Limit dosages and durations to the minimum amount required. Monitor carefully for signs of respiratory despair and sedation.
fentanyl intranasal and pentobarbital the two improve sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom option treatment options are insufficient
CYP3A4 inducers may boost the formation on the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Carefully watch clients having ifosfamide with CYP3A4 inducers for toxicities and take into consideration dose adjustment.
Contraindicated. Coadministration of doravirine with a solid CYP3A inducer could lessen doravirine plasma concentrations and/or effects. Possible for lack of virologic response and doable resistance to doravirine.
benzhydrocodone/acetaminophen and pentobarbital each maximize sedation. Stay away from or Use Alternate Drug. Limit use to sufferers for whom substitute remedy alternatives are insufficient
Reserve concomitant prescribing of such drugs in people for whom other remedy solutions are insufficient. Limit dosages and durations on the minimum required. Keep website an eye on closely for signs of respiratory melancholy and sedation.
pentobarbital will decrease the extent or outcome of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If unable to prevent coadministration of stiripentol with sturdy CYP3A4 inducers, maximize stiripentol dose.
Therapy needs to be administered with caution, if in any way, to sufferers who are mentally frustrated, have suicidal tendencies, or historical past of drug abuse
pentobarbital will decrease the level or effect of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lessen the level or result of paclitaxel protein bound by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
With therapeutic doses of TCAs, barbiturates boost metabolism and decrease blood concentrations of TCAs.
pentobarbital will lower the level or effect of ramelteon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.